Buy Imatib 400mg online USA
What is Imatib used for?
Imatib tablets 400mg are used to treat cancers in which there is a similar genetic abnormality resulting in loss of control of cell growth. Leukaemia is a cancer of the white blood cell that develops in the bone marrow. Several types of leukaemia are classified by the speed at which they grow; being acute if they are fast growing or chronic if they are slow growing. Classification for leukaemia also depends on the type of cell affected; lymphoblastic leukaemia develops from the lymphocytic cells, which form the white cells of the immune system; or myeloid leukaemia, which develops from the myelogenous cells that form the red blood cells, white cells and platelets. Imatib tablets 400mg are used to treat adults and children with chronic myeloid leukaemia (CML are blood cancers caused by either over-production or abnormal development of bone marrow myeloid cells. Imatib tablets 400mg are used to treat some of these cancers associated with gene re-arrangements in the platelet-derived growth factor receptor (PDGFR) gene. Imatib tablets 400mg are also used to treat aggressive systemic mastocytosis (SM), in which mast cells, a type of white blood cell, accumulate and grow in several organs in an uncontrolled manner and also become more active by releasing granules containing inflammatory mediators and chemicals that can have serious effects, including loss of organ function and changes in blood pressure. SM is a rare clonal bone marrow disorder where the cancer cells develop from a single abnormal myeloid bone marrow cell with a gene mutation resulting in the over-activation of the receptor for mast cell growth factor (KIT). However, not all SM cancers have this mutation and Imatib tablets 400mg are used to treat SM where this mutation has not been identified.
How does Imatib work?
Imatib tablets 400mg contain imatinib, a tyrosine kinase (TK) inhibitor that blocks the activity of several different TKs. These TKs are cell surface receptors for many cellular messengers including growth factors. Tyrosine kinase is an enzyme that phosphorylates a protein inside a cell, which is the way many cell processes are regulated and is the first step in a complex cell signalling pathway involved in cell proliferation and survival. Normally activation of these TK receptors is regulated and therefore, cell proliferation is controlled and programmed cell death (apoptosis) takes place. However, over production or over stimulation of this enzyme receptor causes loss of control of cell growth resulting in enhanced cell proliferation, arrest in cell differentiation (when a simple cell becomes specialised for a particular function) and resistance to cell death. This is a common mechanism found in several cancers.
Imatib tablets 400mg contain the active ingredient imatinib, a tyrosine kinase (TK) inhibitor that is used to treat a variety of cancers caused by abnormal TK activity or structure.
Treating cancer with Imatib
Imatib tablets 400mg are used to treat a variety of cancers that are caused by a gene mutation resulting in loss of normal control of cell growth. These include chronic myeloid leukaemia (CML), acute lymphoblastic leukaemia (ALL), myelodysplastic/myeloproliferative diseases (bone marrow cancers); aggressive systemic mastocytosis (SM), cancer of mast cells (white blood cells); metastatic malignant gastrointestinal stromal cancer (GIST) (a rare stomach cancer); hypereosinophilic syndrome (HES) and chronic eosinophilic leukaemia (CEL) (white blood cell cancers) and dermatofibrosarcoma protuberans (DFSP) (a rare skin cancer). Each of these cancers is characterised by a gene mutation resulting in an abnormality in a specific tyrosine kinase (TK), which is an enzyme that is also a receptor for many growth factors in many cells.
What are the side effects of Imatib?
The most commonly reported side effects when taking Imatib tablets 400mg include: nausea, vomiting, diarrhoea, dyspepsia (heartburn), abdominal pain, fatigue, myalgia, asthenia (weakness) muscle pain (myalgia), muscle cramps, joint pain (arthralgia), bone pain, dermatitis, eczema rash, anorexia, weight increase, insomnia, headache, general oedema (fluid retention), swelling around the eye and around the eyelid, increased lacrimation (tear production), conjunctival haemorrhage (red eye or small bleed behind the conjunctiva of the eye), conjunctivitis (eye infection and inflammation), dry eye, blurred vision, flushing, haemorrhage, dyspnoea (difficulty breathing), epistaxis (nosebleed), cough,
When should Imatib not be used?
- are allergic to imatinib or any ingredients in Imatib
- are pregnant or are breastfeeding
- have kidney or liver disease
- have heart disease or are at risk of heart failure
- have had hepatitis B infection, as the virus may become reactivated
- have had your thyroid removed and are receiving thyroid hormone replacement, as your thyroid hormone levels may fall (hypothyroidism)
- are taking medicines that interact with Imatib, including, antibiotics like erythromycin, clarithromycin and rifampin, antifungals like ketoconazole and itraconazole, antivirals like ritonavir and ritonavir for HIV, antiepileptics like carbamazepine and phenytoin, the steroid dexamethasone statins for high cholesterol, calcium channel blockers for high blood pressure, warfarin for heart disease, the immunosuppressive cyclosporine, the analgesic acetaminophen and paracetamol
What medications interact with Imatib?
Several medications interact with Imatib tablets 400mg online and should either not be taken while you are taking Imatib or only after discussion and instruction from your doctor:
Drugs 400mg that cause a serious reaction with Imatib: the analgesics acetaminophen and paracetamol
Drugs that affect Imatib: antibiotics like erythromycin, clarithromycin and rifampin, antifungals like ketoconazole and itraconazole, antivirals like ritonavir and ritonavir for HIV, antiepileptics like carbamazepine and phenytoin, the steroid dexamethasone
Drugs that are affected by Imatib: statins for high cholesterol, calcium channel blockers for high blood pressure, warfarin for heart disease, the immunosuppressive cyclosporine, the analgesics acetaminophen and paracetamol
How should Imatib be taken?
You should take your Imatib tablets 400mg once daily swallowed whole with a glass of water and with food. The dose you take and for how long depends on what you are being treated for and your doctor’s recommendation. You should continue to take your Imatib 400 for as long as you are benefiting from treatment and not having severe side effects, as recommended by your doctor.
How long should you take Imatib?
You should continue to take your Imatib 400 for as long as you are benefiting from treatment and not having severe side effects, as recommended by your doctor.
If you miss a dose of Imatib tablets 400mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.
How should Imatib be stored?
You should store your Imatib below 25°C in a cool dry place.