About Estramustine 140mg Capsules
Estramustine 140mg is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
Estramustine is used to treat metastatic or progressive prostate cancer.
Estramustine may also be used for purposes not listed in this medication guide.
Estramustine 140mg use to treat some types of prostate cancer. In the body, estramustine breaks down into estrogens (estrone, estradiol) and a type of cancer drug (estromustine). This medication is thought to work by increasing estrogens, which interfere with prostate cancer, and by slowing/stopping the growth of cancer cells.
You should not use this medicine if you have a blood clot, swelling of a vein caused by a blood clot, or if you have ever had an allergic reaction to estradiol or nitrogen mustard.
Before taking Estramustine 140mg
You should not use estramustine if you are allergic to it, or if you have:
a blood clot;
swelling of a vein caused by a blood clot; or
if you have ever had an allergic reaction to estradiol or nitrogen mustard.
To make sure estramustine is safe for you, tell your doctor if you have:
a history of blood clot, stroke, or heart attack;
high blood pressure (hypertension);
heart disease or coronary artery disease (atherosclerosis);
congestive heart failure;
epilepsy or other seizure disorder;
kidney disease; or
a metabolic bone disease (such as Paget’s disease).
If a man fathers a baby while using estramustine, the baby may have birth defects. Use condoms to prevent pregnancy during your treatment. Ask your doctor how long you should continue using condoms after you stop taking estramustine.
How should I take estramustine?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
How Take estramustine 140mg -it is take on an empty stomach, at least 1 hour before or 2 hours after a meal.
Take this medicine with water, not with milk or other dairy products.
It may take up to 90 days before you receive the full benefit of taking estramustine. Your doctor will determine how long to treat you with estramustine.
While using estramustine, you may need frequent blood tests. Your blood pressure will also need to be checked often.
This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using estramustine.
Store in the refrigerator, do not freeze.
How estramustine 140mg works
Estramustine belongs to a class of anticancer/cytotoxic drugs called antimicrotubule agents. It works by interfering with production of certain proteins which are necessary for tumor cell growth and reproduction. It also increases the estrogen levels, which in turn interferes with prostate cancer by slowing/stopping the growth of cancer cells.
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop use of Estramustine 140mg and call your doctor at once if you have:
heart problems–shortness of breath (even with mild exertion), swelling, rapid weight gain, chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
signs of a stroke–sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
signs of a blood clot in your leg–pain, swelling, warmth, or redness in one or both legs; or
signs of a blood clot in the lung–chest pain, sudden cough, wheezing, rapid breathing, coughing up blood.
Common side effects may include:
breast swelling or tenderness;
nausea, diarrhea, upset stomach;
swelling, trouble breathing;
leg cramps; or
abnormal liver function tests.
instruction for Dosage of estramustine 140mg
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
X Trant Capsule related warnings
Special precautions for estramustine 140mg
Interaction with alcohol is unknown. Please consult your doctor.
estramustine 140mg is highly unsafe to use during pregnancy.
Human and animal studies have shown significant adverse effects on the foetus. Please consult your doctor.
No information is available on the use of estramustine 140mg during lactation. Please consult your doctor.
It is not known whether estramustine 140mg alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
estramustine 140mg is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of estramustine 140mg may not be needed in these patients. Please consult your doctor.
estramustine 140mg should be used with caution in patients with liver disease. Dose adjustmen of estramustine 140mg may be needed. Please consult your doctor.
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